Dibutylone (bk-DMBDB): Intoxications, Quantitative Confirmations and Metabolism in Authentic Biological Specimens.
Identifieur interne : 000781 ( Main/Exploration ); précédent : 000780; suivant : 000782Dibutylone (bk-DMBDB): Intoxications, Quantitative Confirmations and Metabolism in Authentic Biological Specimens.
Auteurs : Alex J. Krotulski [États-Unis] ; Amanda L A. Mohr [États-Unis] ; Donna M. Papsun [États-Unis] ; Barry K. Logan [États-Unis]Source :
- Journal of analytical toxicology [ 1945-2403 ] ; 2018.
Descripteurs français
- KwdFr :
- 3,4-Méthylènedioxy-amphétamine (analogues et dérivés), 3,4-Méthylènedioxy-amphétamine (analyse), 3,4-Méthylènedioxy-amphétamine (sang), 3,4-Méthylènedioxy-amphétamine (urine), Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Autopsie (MeSH), Biotransformation (MeSH), Corps vitré (composition chimique), Drogues fabriquées clandestinement (analyse), Détection d'abus de substances (méthodes), Examen des urines (MeSH), Femelle (MeSH), Foie (métabolisme), Humains (MeSH), Jeune adulte (MeSH), Microsomes du foie (métabolisme), Mâle (MeSH), Métabolomique (méthodes), N-Méthyl-3,4-méthylènedioxy-amphétamine (analogues et dérivés), N-Méthyl-3,4-méthylènedioxy-amphétamine (analyse), N-Méthyl-3,4-méthylènedioxy-amphétamine (métabolisme), N-Méthyl-3,4-méthylènedioxy-amphétamine (toxicité), Salive (composition chimique), Spectrométrie de masse (MeSH), Toxicologie médicolégale (méthodes).
- MESH :
- analogues et dérivés : 3,4-Méthylènedioxy-amphétamine, N-Méthyl-3,4-méthylènedioxy-amphétamine.
- analyse : 3,4-Méthylènedioxy-amphétamine, Drogues fabriquées clandestinement, N-Méthyl-3,4-méthylènedioxy-amphétamine.
- composition chimique : Corps vitré, Salive.
- métabolisme : Foie, Microsomes du foie, N-Méthyl-3,4-méthylènedioxy-amphétamine.
- méthodes : Détection d'abus de substances, Métabolomique, Toxicologie médicolégale.
- sang : 3,4-Méthylènedioxy-amphétamine.
- toxicité : N-Méthyl-3,4-méthylènedioxy-amphétamine.
- urine : 3,4-Méthylènedioxy-amphétamine.
- Adolescent, Adulte, Adulte d'âge moyen, Autopsie, Biotransformation, Examen des urines, Femelle, Humains, Jeune adulte, Mâle, Spectrométrie de masse.
English descriptors
- KwdEn :
- 3,4-Methylenedioxyamphetamine (analogs & derivatives), 3,4-Methylenedioxyamphetamine (analysis), 3,4-Methylenedioxyamphetamine (blood), 3,4-Methylenedioxyamphetamine (urine), Adolescent (MeSH), Adult (MeSH), Autopsy (MeSH), Biotransformation (MeSH), Designer Drugs (analysis), Female (MeSH), Forensic Toxicology (methods), Humans (MeSH), Liver (metabolism), Male (MeSH), Mass Spectrometry (MeSH), Metabolomics (methods), Microsomes, Liver (metabolism), Middle Aged (MeSH), N-Methyl-3,4-methylenedioxyamphetamine (analogs & derivatives), N-Methyl-3,4-methylenedioxyamphetamine (analysis), N-Methyl-3,4-methylenedioxyamphetamine (metabolism), N-Methyl-3,4-methylenedioxyamphetamine (toxicity), Saliva (chemistry), Substance Abuse Detection (methods), Urinalysis (MeSH), Vitreous Body (chemistry), Young Adult (MeSH).
- MESH :
- chemical , analogs & derivatives : 3,4-Methylenedioxyamphetamine, N-Methyl-3,4-methylenedioxyamphetamine.
- chemical , analysis : 3,4-Methylenedioxyamphetamine, Designer Drugs, N-Methyl-3,4-methylenedioxyamphetamine.
- chemical , blood : 3,4-Methylenedioxyamphetamine.
- chemical , metabolism : N-Methyl-3,4-methylenedioxyamphetamine.
- chemical , toxicity : N-Methyl-3,4-methylenedioxyamphetamine.
- chemical , urine : 3,4-Methylenedioxyamphetamine.
- chemistry : Saliva, Vitreous Body.
- metabolism : Liver, Microsomes, Liver.
- methods : Forensic Toxicology, Metabolomics, Substance Abuse Detection.
- Adolescent, Adult, Autopsy, Biotransformation, Female, Humans, Male, Mass Spectrometry, Middle Aged, Urinalysis, Young Adult.
Abstract
The number of emerging novel stimulants modified based on beta-keto variations of amphetamine-like substances continues to rise. Dibutylone reports described in the medical and toxicological literature are limited, therefore little information is available in terms of quantitative confirmation or metabolism. During this study, authentic human specimens, including blood, urine, vitreous humor, oral fluid and liver were quantitatively and qualitatively analyzed for the presence of dibutylone and butylone, with paired case history and demographic information. Dibutylone concentrations were variable across all specimen types, specifically ranging from 10 to 1,400 ng/mL in postmortem blood specimens. The metabolic profile of dibutylone was mapped by in vitro incubation with human liver microsomes (HLM). Samples were analyzed using a SCIEX TripleTOF® 5600+ quadrupole time-of-flight mass spectrometer. Data processing was conducted using MetabolitePilot™. Authentic human specimens, including blood, urine, vitreous humor, oral fluid and liver, were utilized for in vivo verification of five HLM-generated metabolites in analytically confirmed cases of dibutylone use. Butylone was confirmed as a metabolite of dibutylone, but issues involving co-ingestion of these two novel stimulants or potential co-existence from synthesis lead to ineffectiveness as a true biomarker. Hydrogenation of the beta-ketone of dibutylone resulted in the most prominent metabolite found in human specimens, and its uniqueness to dibutylone over other stimulants leads to its classification as an appropriate biomarker for dibutylone ingestion. This is the first study to map the metabolic profile of dibutylone, including verification in authentic specimens, confirming metabolic conversion to butylone and identifying biomarkers more useful in forensic toxicological drug testing.
DOI: 10.1093/jat/bky022
PubMed: 29554274
Affiliations:
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Le document en format XML
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type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>3,4-Methylenedioxyamphetamine (analogs & derivatives)</term><term>3,4-Methylenedioxyamphetamine (analysis)</term><term>3,4-Methylenedioxyamphetamine (blood)</term><term>3,4-Methylenedioxyamphetamine (urine)</term><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Autopsy (MeSH)</term><term>Biotransformation (MeSH)</term><term>Designer Drugs (analysis)</term><term>Female (MeSH)</term><term>Forensic Toxicology (methods)</term><term>Humans (MeSH)</term><term>Liver (metabolism)</term><term>Male (MeSH)</term><term>Mass Spectrometry (MeSH)</term><term>Metabolomics (methods)</term><term>Microsomes, Liver (metabolism)</term><term>Middle Aged (MeSH)</term><term>N-Methyl-3,4-methylenedioxyamphetamine (analogs & derivatives)</term><term>N-Methyl-3,4-methylenedioxyamphetamine (analysis)</term><term>N-Methyl-3,4-methylenedioxyamphetamine (metabolism)</term><term>N-Methyl-3,4-methylenedioxyamphetamine (toxicity)</term><term>Saliva (chemistry)</term><term>Substance Abuse Detection (methods)</term><term>Urinalysis (MeSH)</term><term>Vitreous Body (chemistry)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>3,4-Méthylènedioxy-amphétamine (analogues et dérivés)</term><term>3,4-Méthylènedioxy-amphétamine (analyse)</term><term>3,4-Méthylènedioxy-amphétamine (sang)</term><term>3,4-Méthylènedioxy-amphétamine (urine)</term><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Autopsie (MeSH)</term><term>Biotransformation (MeSH)</term><term>Corps vitré (composition chimique)</term><term>Drogues fabriquées clandestinement (analyse)</term><term>Détection d'abus de substances (méthodes)</term><term>Examen des urines (MeSH)</term><term>Femelle (MeSH)</term><term>Foie (métabolisme)</term><term>Humains (MeSH)</term><term>Jeune adulte (MeSH)</term><term>Microsomes du foie (métabolisme)</term><term>Mâle (MeSH)</term><term>Métabolomique (méthodes)</term><term>N-Méthyl-3,4-méthylènedioxy-amphétamine (analogues et dérivés)</term><term>N-Méthyl-3,4-méthylènedioxy-amphétamine (analyse)</term><term>N-Méthyl-3,4-méthylènedioxy-amphétamine (métabolisme)</term><term>N-Méthyl-3,4-méthylènedioxy-amphétamine (toxicité)</term><term>Salive (composition chimique)</term><term>Spectrométrie de masse (MeSH)</term><term>Toxicologie médicolégale (méthodes)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>3,4-Methylenedioxyamphetamine</term><term>N-Methyl-3,4-methylenedioxyamphetamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>3,4-Methylenedioxyamphetamine</term><term>Designer Drugs</term><term>N-Methyl-3,4-methylenedioxyamphetamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>3,4-Methylenedioxyamphetamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>N-Methyl-3,4-methylenedioxyamphetamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>N-Methyl-3,4-methylenedioxyamphetamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>3,4-Methylenedioxyamphetamine</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>3,4-Méthylènedioxy-amphétamine</term><term>N-Méthyl-3,4-méthylènedioxy-amphétamine</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>3,4-Méthylènedioxy-amphétamine</term><term>Drogues fabriquées clandestinement</term><term>N-Méthyl-3,4-méthylènedioxy-amphétamine</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Saliva</term><term>Vitreous Body</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Corps vitré</term><term>Salive</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Liver</term><term>Microsomes, Liver</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Forensic Toxicology</term><term>Metabolomics</term><term>Substance Abuse Detection</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Foie</term><term>Microsomes du foie</term><term>N-Méthyl-3,4-méthylènedioxy-amphétamine</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Détection d'abus de substances</term><term>Métabolomique</term><term>Toxicologie médicolégale</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>3,4-Méthylènedioxy-amphétamine</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>N-Méthyl-3,4-méthylènedioxy-amphétamine</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="fr"><term>3,4-Méthylènedioxy-amphétamine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Autopsy</term><term>Biotransformation</term><term>Female</term><term>Humans</term><term>Male</term><term>Mass Spectrometry</term><term>Middle Aged</term><term>Urinalysis</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Autopsie</term><term>Biotransformation</term><term>Examen des urines</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Spectrométrie de masse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The number of emerging novel stimulants modified based on beta-keto variations of amphetamine-like substances continues to rise. Dibutylone reports described in the medical and toxicological literature are limited, therefore little information is available in terms of quantitative confirmation or metabolism. During this study, authentic human specimens, including blood, urine, vitreous humor, oral fluid and liver were quantitatively and qualitatively analyzed for the presence of dibutylone and butylone, with paired case history and demographic information. Dibutylone concentrations were variable across all specimen types, specifically ranging from 10 to 1,400 ng/mL in postmortem blood specimens. The metabolic profile of dibutylone was mapped by in vitro incubation with human liver microsomes (HLM). Samples were analyzed using a SCIEX TripleTOF® 5600+ quadrupole time-of-flight mass spectrometer. Data processing was conducted using MetabolitePilot™. Authentic human specimens, including blood, urine, vitreous humor, oral fluid and liver, were utilized for in vivo verification of five HLM-generated metabolites in analytically confirmed cases of dibutylone use. Butylone was confirmed as a metabolite of dibutylone, but issues involving co-ingestion of these two novel stimulants or potential co-existence from synthesis lead to ineffectiveness as a true biomarker. Hydrogenation of the beta-ketone of dibutylone resulted in the most prominent metabolite found in human specimens, and its uniqueness to dibutylone over other stimulants leads to its classification as an appropriate biomarker for dibutylone ingestion. This is the first study to map the metabolic profile of dibutylone, including verification in authentic specimens, confirming metabolic conversion to butylone and identifying biomarkers more useful in forensic toxicological drug testing.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29554274</PMID><DateCompleted><Year>2018</Year><Month>12</Month><Day>18</Day></DateCompleted><DateRevised><Year>2019</Year><Month>01</Month><Day>18</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1945-2403</ISSN><JournalIssue CitedMedium="Internet"><Volume>42</Volume><Issue>7</Issue><PubDate><Year>2018</Year><Month>Sep</Month><Day>01</Day></PubDate></JournalIssue><Title>Journal of analytical toxicology</Title><ISOAbbreviation>J Anal Toxicol</ISOAbbreviation></Journal><ArticleTitle>Dibutylone (bk-DMBDB): Intoxications, Quantitative Confirmations and Metabolism in Authentic Biological Specimens.</ArticleTitle><Pagination><MedlinePgn>437-445</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/jat/bky022</ELocationID><Abstract><AbstractText>The number of emerging novel stimulants modified based on beta-keto variations of amphetamine-like substances continues to rise. Dibutylone reports described in the medical and toxicological literature are limited, therefore little information is available in terms of quantitative confirmation or metabolism. During this study, authentic human specimens, including blood, urine, vitreous humor, oral fluid and liver were quantitatively and qualitatively analyzed for the presence of dibutylone and butylone, with paired case history and demographic information. Dibutylone concentrations were variable across all specimen types, specifically ranging from 10 to 1,400 ng/mL in postmortem blood specimens. The metabolic profile of dibutylone was mapped by in vitro incubation with human liver microsomes (HLM). Samples were analyzed using a SCIEX TripleTOF® 5600+ quadrupole time-of-flight mass spectrometer. Data processing was conducted using MetabolitePilot™. Authentic human specimens, including blood, urine, vitreous humor, oral fluid and liver, were utilized for in vivo verification of five HLM-generated metabolites in analytically confirmed cases of dibutylone use. Butylone was confirmed as a metabolite of dibutylone, but issues involving co-ingestion of these two novel stimulants or potential co-existence from synthesis lead to ineffectiveness as a true biomarker. Hydrogenation of the beta-ketone of dibutylone resulted in the most prominent metabolite found in human specimens, and its uniqueness to dibutylone over other stimulants leads to its classification as an appropriate biomarker for dibutylone ingestion. This is the first study to map the metabolic profile of dibutylone, including verification in authentic specimens, confirming metabolic conversion to butylone and identifying biomarkers more useful in forensic toxicological drug testing.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Krotulski</LastName><ForeName>Alex J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Center for Forensic Science Research and Education at the Fredric Rieders Family Foundation, 2300 Stratford Ave, Willow Grove, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mohr</LastName><ForeName>Amanda L A</ForeName><Initials>ALA</Initials><AffiliationInfo><Affiliation>Center for Forensic Science Research and Education at the Fredric Rieders Family Foundation, 2300 Stratford Ave, Willow Grove, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Papsun</LastName><ForeName>Donna M</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>NMS Labs, 3701 Welsh Rd, Willow Grove, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Logan</LastName><ForeName>Barry K</ForeName><Initials>BK</Initials><AffiliationInfo><Affiliation>Center for Forensic Science Research and Education at the Fredric Rieders Family Foundation, 2300 Stratford Ave, Willow Grove, PA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>NMS Labs, 3701 Welsh Rd, Willow Grove, PA, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Anal Toxicol</MedlineTA><NlmUniqueID>7705085</NlmUniqueID><ISSNLinking>0146-4760</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015198">Designer Drugs</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C000629374">dibutylone</NameOfSubstance></Chemical><Chemical><RegistryNumber>4764-17-4</RegistryNumber><NameOfSubstance UI="D015104">3,4-Methylenedioxyamphetamine</NameOfSubstance></Chemical><Chemical><RegistryNumber>KE1SEN21RM</RegistryNumber><NameOfSubstance UI="D018817">N-Methyl-3,4-methylenedioxyamphetamine</NameOfSubstance></Chemical><Chemical><RegistryNumber>X72T4EQ4FQ</RegistryNumber><NameOfSubstance UI="C544130">2-methylamino-1-(3,4-methylenedioxyphenyl)butan-1-one</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D015104" MajorTopicYN="N">3,4-Methylenedioxyamphetamine</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001344" MajorTopicYN="N">Autopsy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001711" MajorTopicYN="N">Biotransformation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015198" MajorTopicYN="N">Designer Drugs</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053593" MajorTopicYN="N">Forensic Toxicology</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013058" MajorTopicYN="N">Mass Spectrometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055432" MajorTopicYN="N">Metabolomics</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008862" MajorTopicYN="N">Microsomes, Liver</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018817" MajorTopicYN="N">N-Methyl-3,4-methylenedioxyamphetamine</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012463" MajorTopicYN="N">Saliva</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015813" MajorTopicYN="N">Substance Abuse Detection</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016482" MajorTopicYN="N">Urinalysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014822" MajorTopicYN="N">Vitreous Body</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>11</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>02</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>3</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>12</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>3</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29554274</ArticleId><ArticleId IdType="pii">4937964</ArticleId><ArticleId IdType="doi">10.1093/jat/bky022</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Krotulski, Alex J" sort="Krotulski, Alex J" uniqKey="Krotulski A" first="Alex J" last="Krotulski">Alex J. Krotulski</name></region><name sortKey="Logan, Barry K" sort="Logan, Barry K" uniqKey="Logan B" first="Barry K" last="Logan">Barry K. Logan</name><name sortKey="Logan, Barry K" sort="Logan, Barry K" uniqKey="Logan B" first="Barry K" last="Logan">Barry K. Logan</name><name sortKey="Mohr, Amanda L A" sort="Mohr, Amanda L A" uniqKey="Mohr A" first="Amanda L A" last="Mohr">Amanda L A. Mohr</name><name sortKey="Papsun, Donna M" sort="Papsun, Donna M" uniqKey="Papsun D" first="Donna M" last="Papsun">Donna M. Papsun</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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{{Explor lien
|wiki= Bois
|area= WillowV1
|flux= Main
|étape= Exploration
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|clé= pubmed:29554274
|texte= Dibutylone (bk-DMBDB): Intoxications, Quantitative Confirmations and Metabolism in Authentic Biological Specimens.
}}
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